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PRE-084 hydrochloride

PRE-084 hydrochloride

  • CAT Number: I004784
  • CAS Number: 75136-54-8
  • Molecular Formula: C19H28ClNO3
  • Molecular Weight: 353.887
  • Purity: ≥95%
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PRE-084 hydrochloride (Cat.No:I004784) is a selective sigma-1 receptor agonist. It has been studied for its potential therapeutic applications in various neurological disorders, including neurodegenerative diseases, pain management, and psychiatric disorders. PRE-084 hydrochloride exhibits neuroprotective, antidepressant, and analgesic effects, making it a subject of interest for further research in these areas.

Catalog Number I004784
CAS Number 75136-54-8
Molecular Formula

C19H28ClNO3

Purity 95%
Target Sigma Receptor
Solubility DMSO: ≥ 34 mg/mL
Storage Store at RT
IC50 44 nM
IUPAC Name 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate;hydrochloride
InChI InChI=1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H
InChIKey QUJWFJNHTBKCLU-UHFFFAOYSA-N
SMILES C1CCC(CC1)(C2=CC=CC=C2)C(=O)OCCN3CCOCC3.Cl
Reference

<p style=/line-height:25px/>
<br>[1]. Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259(2):543-550.
<br>[2]. Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-232.
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