Prazosin Hydrochloride

• CAT Number: A000734
• CAS Number: 19237-84-4
• Molecular Formula: C19H22ClN5O4
• Molecular Weight: 419.9
• Purity: ≥95%
• Target: Adrenergic Receptor
• Solubility: Limited solubility
• Storage: -20°C
• InChI: 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
• InChIKey: WFXFYZULCQKPIP-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl

Prazosin Hydrochloride is a selective adrenergic alpha-1 antagonist used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud disease, prostratic hypertrophy and urinary retention.

Reference

1: Shen X, Xu Q, Xu S, Li J, Zhang N, Zhang L. Preparation and transdermal
diffusion evaluation of the prazosin hydrochloride-loaded electrospun poly(vinyl
alcohol) fiber mats. J Nanosci Nanotechnol. 2014 Jul;14(7):5258-65. PubMed PMID:
24758013.

2: Kulkarni RV, Sreedhar V, Mutalik S, Setty CM, Sa B. Interpenetrating network
hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled
release of prazosin hydrochloride through skin. Int J Biol Macromol. 2010 Nov
1;47(4):520-7. doi: 10.1016/j.ijbiomac.2010.07.009. Epub 2010 Aug 1. PubMed PMID:
20678518.

3: Kabbaj M, Morley-Fletcher S, Le Moal M, Maccari S. Individual differences in
the effects of chronic prazosin hydrochloride treatment on hippocampal
mineralocorticoid and glucocorticoid receptors. Eur J Neurosci. 2007
Jun;25(11):3312-8. PubMed PMID: 17552999.

4: Liu L, Wang J, Zhu S. Delivery of prazosin hydrochloride from osmotic pump
system prepared by coating the core tablet with an indentation. Drug Deliv. 2007
Apr;14(4):219-24. PubMed PMID: 17497354.

5: Liu L, Zhu S. Preparation and characterization of inclusion complexes of
prazosin hydrochloride with beta-cyclodextrin and
hydroxypropyl-beta-cyclodextrin. J Pharm Biomed Anal. 2006 Jan 23;40(1):122-7.
Epub 2005 Aug 10. PubMed PMID: 16095859.

6: Chernyshev VV, Stephens PW, Yatsenko AV, Ryabova OB, Makarov VA. Structural
characterization of prazosin hydrochloride and prazosin free base. J Pharm Sci.
2004 Dec;93(12):3090-5. PubMed PMID: 15514987.

7: Legnerová Z, Huclová J, Thun R, Solich P. Sensitive fluorimetric method based
on sequential injection analysis technique used for dissolution studies and
quality control of prazosin hydrochloride in tablets. J Pharm Biomed Anal. 2004
Jan 27;34(1):115-21. PubMed PMID: 14738925.

8: Reddy LH, Ghosh B. Enhancer aided in vitro permeation of atenolol and prazosin
hydrochloride through mice skin. Indian J Exp Biol. 2001 Jan;39(1):47-51. PubMed
PMID: 11349525.

9: Kataoka H, Kumagai H, Hanai H. Treating familial Mediterranean fever with
prazosin hydrochloride. Ann Intern Med. 1998 Sep 1;129(5):424. PubMed PMID:
9735077.

10: Altiokka G, Tunçel M. Differential pulse polarographic determination of
prazosin hydrochloride in tablets. Pharmazie. 1997 May;52(5):401-2. PubMed PMID:
9183792.