Pranoprofen

• CAT Number: A001104
• CAS Number: 52549-17-4
• Molecular Formula: C15H13NO3
• Molecular Weight: 255.3
• Purity: ≥95%
• Target: COX
• Storage: 3 years -20C powder
• InChIKey: TVQZAMVBTVNYLA-UHFFFAOYSA-N

Pranoprofen is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.Pranoprofen inhibits ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Pranoprofen inhibits ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. Pranoprofen alone induces eIF2alpha phosphorylation, which is further increased by ER stress. Pranoprofen inhibits ER stress-induced X-box-binding protein 1 (XBP-1) splicing in the primary cultured glial cells.Pranoprofen is orally administered, urinary and fecal excretions of the radioactivity within 3 days are 81.1% and 18.7% of the dose in mice, 51.5% and 39.4% in rats, 81.8% and 9.0% in guinea pigs, and 93.2% and 3.6% in rabbits, respectively.