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Pramipexole 2HCl Monohydrate

Pramipexole 2HCl Monohydrate

  • CAT Number: A001063
  • CAS Number: 191217-81-9
  • Molecular Formula: C10H21Cl2N3OS
  • Molecular Weight: 302.258
  • Purity: ≥95%
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Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson/’s disease.<br>Pramipexole, a chemically novel dopamine agonist used for the treatment of Parkinson/’s disease symptoms, possesses antioxidant activity and is neuroprotective toward substantia nigral dopamine neurons in hypoxic-ischemic and methamphetamine models. Pramipexole reduces the levels of oxygen radicals produced by methylpyridinium ion (MPP+) both when incubated with SH-SY5Y cells and when perfused into rat striatum. Pramipexole also exhibits a concentration-dependent inhibition of opening of the mitochondrial transition pore induced by calcium and phosphate or MPP+.<br>Pramipexole (0.001-1 mg/kg s.c.) reduces exploratory locomotor activity in mice.

Catalog Number A001063
CAS Number 191217-81-9
Molecular Formula

C10H21Cl2N3OS

Purity 95%
Target Dopamine Receptor
Solubility Soluble in DMSO > 10 mM
Storage 3 years -20C powder
IUPAC Name (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;hydrate;dihydrochloride
InChI InChI=1S/C10H17N3S.2ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H;1H2/t7-;;;/m0.../s1
InChIKey APVQOOKHDZVJEX-QTPLPEIMSA-N
SMILES CCCNC1CCC2=C(C1)SC(=N2)N.O.Cl.Cl

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