Practolol

• CAT Number: R056390
• CAS Number: 6673-35-4
• Molecular Formula: C14H22N2O3
• Molecular Weight: 266.34
• Purity: ≥95%
• Synonyms: N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
• InChI: InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
• InChIKey: DURULFYMVIFBIR-UHFFFAOYSA-N
• SMILES: CC(C)NCC(COC1=CC=C(C=C1)NC(=O)C)O

Practolol (Cat No.: R056390) is a first-generation selective β1-adrenergic receptor blocker that was once used clinically to manage angina pectoris, cardiac arrhythmias, and hypertension. By selectively blocking β1 receptors in the heart, Practolol reduces heart rate and cardiac output while minimizing effects on β2 receptors in the lungs and vasculature. Although it was withdrawn from therapeutic use due to serious adverse reactions, Practolol remains important in cardiovascular research, serving as a reference compound for studying β-blocker pharmacology and adrenergic signaling mechanisms.

Reference

[1]. Iakovidis D, et, al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85.
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[2]. Adashi EY, et, al. Stimulation of beta 2-adrenergic responsiveness by follicle-stimulating hormone in rat granulosa cells in vitro and in vivo. Endocrinology. 1981 Jun;108(6):2170-8.
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[3]. Marshall RJ, et, al. Comparative effects of propranolol and practolol in the early stages of experimental canine myocardial infarction. Br J Pharmacol. 1976 Jun;57(2):295-303.
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