PR-924

• CAT Number: I015541
• CAS Number: 1416709-79-9
• Molecular Formula: C37H38N4O5
• Molecular Weight: 618.72
• Purity: ≥95%
• Synonyms: N-[(2R)-1-[[(2S)-3-(1H-indol-3-yl)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methyl-1H-indene-2-carboxamide
• InChI: InChI=1S/C37H38N4O5/c1-22-27-14-8-7-13-25(27)18-29(22)35(44)39-23(2)34(43)41-32(19-26-20-38-30-16-10-9-15-28(26)30)36(45)40-31(33(42)37(3)21-46-37)17-24-11-5-4-6-12-24/h4-16,20,23,31-32,38H,17-19,21H2,1-3H3,(H,39,44)(H,40,45)(H,41,43)/t23-,31+,32+,37-/m1/s1
• InChIKey: ADBUEVSHEJICCM-LZNHGOJSSA-N
• SMILES: CC1=C(CC2=CC=CC=C12)C(=O)N[C@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)[C@]6(CO6)C

PR-924（Cat No.:I015541）is a selective, irreversible inhibitor of the immunoproteasome subunit LMP-7 (β5i), a catalytic component critical for antigen processing and immune regulation. By covalently binding to LMP-7, PR-924 blocks chymotrypsin-like proteolytic activity, leading to altered protein turnover, reduced survival of malignant cells, and modulation of immune responses. It has shown promise in multiple myeloma and hematologic malignancy models, where immunoproteasome function is essential for tumor growth. PR-924 serves as a valuable tool in cancer research, immunology, and drug development, advancing understanding of immunoproteasome biology and therapeutic targeting.