PQR-309

• CAT Number: I000865
• CAS Number: 1225037-39-7
• Molecular Formula: C₁₇H₂₀F₃N₇O₂
• Molecular Weight: 411.39
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: -20°C
• InChI: InChI=1S/C17H20F3N7O2/c18-17(19,20)12-9-13(21)22-10-11(12)14-23-15(26-1-5-28-6-2-26)25-16(24-14)27-3-7-29-8-4-27/h9-10H,1-8H2,(H2,21,22)
• InChIKey: ADGGYDAFIHSYFI-UHFFFAOYSA-N
• SMILES: C1COCCN1C2=NC(=NC(=N2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4

PQR-309(CAT: I000865) is a potent inhibitor of phosphoinositide 3-kinase (PI3K). It specifically inhibits the phosphorylation of protein kinase B (PKB/Akt) and ribosomal protein S6 (pS6), which are downstream targets of the PI3K signaling pathway. By blocking this pathway, PQR-309 has the potential to inhibit cell growth, proliferation, and survival. PI3K inhibitors like PQR-309 are being investigated for their therapeutic potential in various diseases, including cancer, where dysregulation of the PI3K pathway is often observed.

Reference

[1]. Cmiljanovic Vladimir, et al. Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes and their preparation. From PCT Int. Appl. (2010), WO 2010052569 A2 20100514.