Pomalidomide-PEG4-azide

• CAT Number: I015695
• CAS Number: 2271036-47-4
• Molecular Formula: C23H30N6O8
• Molecular Weight: 518.52
• Purity: ≥95%
• Synonyms: 4-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• InChI: InChI=1S/C23H30N6O8/c24-28-26-7-9-35-11-13-37-15-14-36-12-10-34-8-6-25-17-3-1-2-16-20(17)23(33)29(22(16)32)18-4-5-19(30)27-21(18)31/h1-3,18,25H,4-15H2,(H,27,30,31)
• InChIKey: SMHKJRVPSDESLS-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCN=[N+]=[N-]

Pomalidomide-PEG4-azide（Cat No.:I015695）is a bifunctional chemical probe designed for targeted protein degradation and bioconjugation research. The pomalidomide moiety binds cereblon (CRBN), an E3 ubiquitin ligase component, enabling recruitment of target proteins for ubiquitination and degradation in PROTAC development. The PEG4 spacer provides flexibility, solubility, and reduced steric hindrance, while the terminal azide group allows copper-catalyzed or strain-promoted click chemistry for site-specific conjugation. This compound is widely applied in chemical biology, medicinal chemistry, and drug discovery to design novel degraders and investigate therapeutic strategies involving CRBN-mediated protein knockdown.