Pomalidomide-PEG3-azide

• CAT Number: I044661
• CAS Number: 2267306-15-8
• Molecular Formula: C21H24N6O8
• Molecular Weight: 488.45
• Purity: ≥95%
• Synonyms: 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]acetamide
• InChI: InChI=1S/C21H24N6O8/c22-26-23-6-7-33-8-9-34-10-11-35-12-17(29)24-14-3-1-2-13-18(14)21(32)27(20(13)31)15-4-5-16(28)25-19(15)30/h1-3,15H,4-12H2,(H,24,29)(H,25,28,30)
• InChIKey: DUTLUBRCOXPZLI-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)COCCOCCOCCN=[N+]=[N-]

Pomalidomide-PEG3-azide（Cat No.:I044661）is a functionalized derivative of pomalidomide, a potent immunomodulatory drug (IMiD), conjugated with a triethylene glycol (PEG3) linker terminating in an azide group. This bifunctional molecule is commonly used in the design of PROTACs (proteolysis-targeting chimeras) and other targeted protein degradation platforms. The pomalidomide moiety binds to cereblon (CRBN), a component of the E3 ubiquitin ligase complex, enabling selective recruitment of target proteins. The azide handle facilitates bioorthogonal click chemistry for conjugation. Pomalidomide-PEG3-azide is a powerful tool for studying targeted degradation in drug discovery and chemical biology.