For research use only. Not for therapeutic Use.
Pomalidomide-amido-C3-COOH（Cat No.:I015138）is a thalidomide analog derivative featuring a C3-amido-carboxylic acid linker that allows conjugation for targeted protein degradation studies. Built on the pomalidomide scaffold, it retains cereblon-binding properties, enabling its use as a ligand in PROTAC (proteolysis-targeting chimera) design. The carboxyl group provides a versatile handle for coupling to other molecules, such as inhibitors or ligands, to direct selective degradation of disease-relevant proteins. This compound is valuable for chemical biology and drug discovery, supporting research into novel therapeutic approaches for cancer and immune-mediated disorders.
| CAS Number | 2162120-77-4 |
| Synonyms | 5-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-5-oxopentanoic acid |
| Molecular Formula | C18H17N3O7 |
| Purity | ≥95% |
| IUPAC Name | 5-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-5-oxopentanoic acid |
| InChI | InChI=1S/C18H17N3O7/c22-12(5-2-6-14(24)25)19-10-4-1-3-9-15(10)18(28)21(17(9)27)11-7-8-13(23)20-16(11)26/h1,3-4,11H,2,5-8H2,(H,19,22)(H,24,25)(H,20,23,26) |
| InChIKey | JJQUHUNMWFLJBM-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)CCCC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
