PMX205

• CAT Number: I008791
• CAS Number: 514814-49-4
• Molecular Formula: C45H62N10O6
• Molecular Weight: 839.1
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: -20°C
• InChI: InChI=1S/C45H62N10O6/c46-45(47)49-24-9-18-34-40(57)48-23-10-19-35(51-39(56)22-21-29-12-3-1-4-13-29)44(61)55-25-11-20-38(55)43(60)54-36(26-30-14-5-2-6-15-30)41(58)53-37(42(59)52-34)27-31-28-50-33-17-8-7-16-32(31)33/h1,3-4,7-8,12-13,16-17,28,30,34-38,50H,2,
• InChIKey: VATFHFJULBPYLM-ILOBPARPSA-N
• SMILES: O=C([C@]([H])(CC1=CNC2=C1C=CC=C2)NC([C@@H](CC3CCCCC3)NC([C@]4(N5CCC4)[H])=O)=O)N[C@@H](CCCNC(N)=N)C(NCCC[C@@]([H])(C5=O)NC(CCC6=CC=CC=C6)=O)=O

PMX205 is a C5a receptor antagonist. PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10. Pharmacological inhibition of C5a activity by PMX205 is efficacious in preventing DSS-induced colitis, providing further evidence that targeting CD88 in IBD patients could be a valuable therapeutic option PMX205 reduces inflammation in a murine model of allergic asthma.

Reference

1:Treatment with the C5a receptor/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma. Staab EB, Sanderson SD, Wells SM, Poole JA.Int Immunopharmacol. 2014 Aug;21(2):293-300. doi: 10.1016/j.intimp.2014.05.008. Epub 2014 May 21. PMID: 24859057 Free PMC Article2:The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10. Jain U, Woodruff TM, Stadnyk AW.Br J Pharmacol. 2013 Jan;168(2):488-501. doi: 10.1111/j.1476-5381.2012.02183.x. PMID: 22924972 Free PMC Article3:Improving the Fmoc Solid Phase Synthesis of the Cyclic Hexapeptide Complement C5a Antagonist, PMX205. Delisle Milton RC, Milton SC, Chamberlin AR.Int J Pept Res Ther. 2011 Dec;17(4):337-342. PMID: 22707924 Free PMC Article