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Pleconaril

Pleconaril

  • CAT Number: I001915
  • CAS Number: 153168-05-9
  • Molecular Formula: C18H18F3N3O3
  • Molecular Weight: 381.35
  • Purity: ≥95%
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<p style=/line-height:25px/>Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM.<br>Target: enterovirus<br>Pleconaril is a capsid inhibitor designed to dock within a hydrophobic pocket formed by the capsid proteins VP1, VP3 and VP2. Pleconaril leads to stiffening of the capsid structure, preventing RNA release into the cell. Pleconaril has been used as treatment on a compassionateuse basis in neonates and immunodeficient patients with severe EV infections.</p>

Catalog Number I001915
CAS Number 153168-05-9
Molecular Formula

C18H18F3N3O3

Purity 95%
Target enterovirus
Solubility 10 mM in DMSO
Storage Store at -20C
InChI InChI=1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
InChIKey KQOXLKOJHVFTRN-UHFFFAOYSA-N
SMILES FC(C1=NC(C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2)=NO1)(F)F
Reference

</br>1:[A randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis]. Hernández M.Rev Chilena Infectol. 2016 Jun;33(3):359. doi: 10.4067/S0716-10182016000300021. Spanish. No abstract available. PMID: 27598292 Free Article</br>2:A Randomized, Double-Blind, Placebo-Controlled Trial of Pleconaril for the Treatment of Neonates With Enterovirus Sepsis. Abzug MJ, Michaels MG, Wald E, Jacobs RF, Romero JR, Sánchez PJ, Wilson G, Krogstad P, Storch GA, Lawrence R, Shelton M, Palmer A, Robinson J, Dennehy P, Sood SK, Cloud G, Jester P, Acosta EP, Whitley R, Kimberlin D; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group..J Pediatric Infect Dis Soc. 2016 Mar;5(1):53-62. doi: 10.1093/jpids/piv015. Epub 2015 Apr 16. PMID: 26407253 Free PMC Article</br>3:In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses. Lacroix C, Laconi S, Angius F, Coluccia A, Silvestri R, Pompei R, Neyts J, Leyssen P.Virol J. 2015 Jul 14;12:106. doi: 10.1186/s12985-015-0330-4. PMID: 26169596 Free PMC Article</br>4:Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds. Bernard A, Lacroix C, Cabiddu MG, Neyts J, Leyssen P, Pompei R.Antivir Chem Chemother. 2015 Apr;24(2):56-61. doi: 10.1177/2040206615589035. Epub 2015 Jun 11. PMID: 26071135 </br>5:Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient. Benschop KS, Wildenbeest JG, Koen G, Minnaar RP, van Hemert FJ, Westerhuis BM, Pajkrt D, van den Broek PJ, Vossen AC, Wolthers KC.J Gen Virol. 2015 Mar;96(Pt 3):571-9. doi: 10.1099/vir.0.069773-0. Epub 2014 Nov 13. PMID: 25395595 </br>6:In-Silico screening of Pleconaril and its novel substituted derivatives with Neuraminidase of H1N1 Influenza strain. Hussain Basha S, Prasad RN.BMC Res Notes. 2012 Feb 17;5:105. doi: 10.1186/1756-0500-5-105. PMID: 22340192 Free PMC Article</br>7:Pleconaril revisited: clinical course of chronic enteroviral meningoencephalitis after treatment correlates with in vitro susceptibility. Wildenbeest JG, van den Broek PJ, Benschop KS, Koen G, Wierenga PC, Vossen AC, Kuijpers TW, Wolthers KC.Antivir Ther. 2012;17(3):459-66. doi: 10.3851/IMP1936. Epub 2011 Oct 24. PMID: 22293148 </br>8:In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection. Zhang G, Zhou F, Gu B, Ding C, Feng D, Xie F, Wang J, Zhang C, Cao Q, Deng Y, Hu W, Yao K.Arch Virol. 2012 Apr;157(4):669-79. doi: 10.1007/s00705-011-1222-6. Epub 2012 Jan 15. PMID: 22245989 </br>9:Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia. van de Ven AA, Douma JW, Rademaker C, van Loon AM, Wensing AM, Boelens JJ, Sanders EA, van Montfrans JM.Antivir Ther. 2011;16(4):611-4. doi: 10.3851/IMP1792. PMID: 21685550 </br>10:New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3. Schmidtke M, Wutzler P, Zieger R, Riabova OB, Makarov VA.Antiviral Res. 2009 Jan;81(1):56-63. doi: 10.1016/j.antiviral.2008.09.002. Epub 2008 Oct 7. PMID: 18840470

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