PKR Inhibitor - CAS 608512-97-6

C16, also known as GW-506033X or PKR Inhibitor. C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. GW-506033X protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. PKR inhibitor C16 binds efficiently with human microtubule affinity-regulating kinase 4.

Catalog Number: R023730

CAS Number: 608512-97-6

Molecular Formula: C13H8N4OS

Molecular Weight:268.3

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Synonyms6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one; 6,8-Dihydro-8-(1H-imidazol-4-ylmethylene)- 7H-pyrrolo[2,3-g]benzothiazol-7-one; GW 506033X


Molecular Formula: C13H8N4OS
Molecular Weight268.3
Target:Broad Spectrum Protein Kinase Inhibitor
SolubilitySoluble in DMSO
StorageStore at -20°C

Computed Descriptor