PKCβ inhibitor 1

• CAT Number: I016271
• CAS Number: 257879-35-9
• Molecular Formula: C₂₄H₂₁N₅O₂
• Molecular Weight: 411.46
• Purity: ≥95%
• IUPAC Name: 3-anilino-4-[1-(3-imidazol-1-ylpropyl)indol-3-yl]pyrrole-2,5-dione
• InChI: InChI=1S/C24H21N5O2/c30-23-21(22(24(31)27-23)26-17-7-2-1-3-8-17)19-15-29(20-10-5-4-9-18(19)20)13-6-12-28-14-11-25-16-28/h1-5,7-11,14-16H,6,12-13H2,(H2,26,27,30,31)
• InChIKey: KIWODJBCHRADND-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)NC2=C(C(=O)NC2=O)C3=CN(C4=CC=CC=C43)CCCN5C=CN=C5

PKCβ inhibitor 1（Cat No.:I016271） is a highly potent and selective inhibitor of protein kinase C beta (PKCβ) with significant ATP-competitive activity. It exhibits IC50 values of 21 nM and 5 nM for human PKCβ1 and PKCβ2, respectively. Compared to other PKC isozymes such as PKCα, PKCγ, and PKCε, PKCβ inhibitor 1 demonstrates more than 60-fold selectivity. This selective inhibition of PKCβ isoforms makes it a valuable tool in studying PKCβ-mediated signaling pathways and may have potential therapeutic applications in diseases where PKCβ is involved.

Reference

[1]. Tanaka M, et al. Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4.[2]. Saba NS, et al. Protein kinase C-beta inhibition induces apoptosis and inhibits cell cycle progression in acquired immunodeficiency syndrome-related non-hodgkin lymphoma cells. J Investig Med. 2012 Jan;60(1):29-38.