Pioglitazone Hydrochloride

• CAT Number: I008770
• CAS Number: 112529-15-4 (HCl)
• Molecular Formula: C19H21ClN2O3S
• Molecular Weight: 392.898
• Purity: ≥95%
• Synonyms: Pioglitazone Hydrochloride; Pioglitazone HCl; Actos; U-72107A; AD 4833; AD-4833; pioglitazone; pioglitazone hydrochloride; U 72107A; U-72107A; U72,107A;;5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride
• Solubility: Soluble in DMSO, not in water
• Storage: -20°C
• IUPAC Name: 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride
• InChI: InChI=1S/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H
• InChIKey: GHUUBYQTCDQWRA-UHFFFAOYSA-N
• SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl

Pioglitazone Hydrochloride is a thiazolidinedione compound described to produce antiinflammatory and antiarteriosclerotic effects. Pioglitazone is demonstrated to prevent L-NAME-induced coronary inflammation and arteriosclerosis and to suppress increased TNF-α mRNA produced by aspirin-induced gastric mucosal injury. Pioglitazone Hydrochloride is an activator of PPAR γ.

Reference

1:Effects of vitamin D combined with pioglitazone hydrochloride on bone mineral density and bone metabolism in Type 2 diabetic nephropathy. Wang LX, Wang N, Xu QL, Yan W, Dong L, Li BL.Biosci Rep. 2017 Mar 27;37(2). pii: BSR20160544. doi: 10.1042/BSR20160544. Print 2017 Apr 28. PMID: 28153916 2:[Pioglitazone hydrochloride a instrumental analytical perspective by Raman spectroscopy and HPLC]. Vértiz-Beltrán JF, Avila-Rodríguez R, Terrones-Gurrola R, Abelardo Camacho L, Rangel-López A, Campos-Cantón I, Vértiz-Hernández AA.Rev Invest Clin. 2014 Jul-Aug;66(4):351-8. Spanish. PMID: 25695301 3:Design, statistical optimisation, characterisation and pharmacodynamic studies on Pioglitazone hydrochloride floating microparticles. Rao BP, Baby B, Mathews R, Rajarajan S, Haritha P, Ramesh K, Gupta NV.J Microencapsul. 2014;31(4):406-14. doi: 10.3109/02652048.2013.863399. Epub 2014 Apr 3. PMID: 24697182 4:Pioglitazone hydrochloride: chemopreventive potential and development of site-specific drug delivery systems. Sinha VR, Sethi S.Drug Deliv. 2015 May;22(3):408-17. doi: 10.3109/10717544.2014.887156. Epub 2014 Feb 19. PMID: 24547712 5:Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride. Chowdary YA, Raparla R, Madhuri M.J Pharm (Cairo). 2014;2014:848243. doi: 10.1155/2014/848243. Epub 2014 May 12. PMID: 26556204 Free PMC Article6:Multivariate chemometric assisted analysis of metformin hydrochloride, gliclazide and pioglitazone hydrochloride in bulk drug and dosage forms. Bhaskar R, Bhaskar R, Sagar MK, Saini V.Adv Pharm Bull. 2013;3(1):79-84. doi: 10.5681/apb.2013.013. Epub 2013 Feb 7. PMID: 24312816 Free PMC Article7:RP-HPLC method development and validation for simultaneous estimation of atorvastatin calcium and pioglitazone hydrochloride in pharmaceutical dosage form. Peraman R, Mallikarjuna S, Ammineni P, Kondreddy Vk.J Chromatogr Sci. 2014 Oct;52(9):1038-42. doi: 10.1093/chromsci/bmt156. Epub 2013 Oct 22. PMID: 24152592 8:[Pharmacokinetic interaction of pioglitazone hydrochloride and atorvastatin calcium in Beagle dogs]. Chen HL, Zhang WP, Yang FY, Wang XY, Yang WC, Dang HW.Yao Xue Xue Bao. 2013 May;48(5):741-5. Chinese. PMID: 23888699 9:RP-LC method for the simultaneous determination of gliquidone, pioglitazone hydrochloride, and atorvastatin in formulations and human serum. Mirza AZ, Arayne MS, Sultana N.J AOAC Int. 2013 Jan-Feb;96(1):56-9. PMID: 23513958 10:In vitro-in vivo evaluation of fast-dissolving tablets containing solid dispersion of pioglitazone hydrochloride. Pandit V, Pai RS, Devi K, Suresh S.J Adv Pharm Technol Res. 2012 Jul;3(3):160-70. doi: 10.4103/2231-4040.101008. PMID: 23057002 Free PMC Article