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PIK-294

PIK-294

  • CAT Number: I005385
  • CAS Number: 900185-02-6
  • Molecular Formula: C₂₈H₂₃N₇O₂
  • Molecular Weight: 489.53
  • Purity: ≥95%
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PIK-294 (Cat.No:I005385) is a selective inhibitor of phosphoinositide 3-kinase (PI3K) p110δ isoform. It has shown promising results in preclinical studies as an anticancer agent, particularly in hematological malignancies. PIK-294 inhibits aberrant PI3K signaling, leading to cell cycle arrest and apoptosis. 

Catalog Number I005385
CAS Number 900185-02-6
Synonyms

2-[[4-amino-3-(3-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one

Molecular Formula

C₂₈H₂₃N₇O₂

Purity 95%
Target PI3K
Solubility DMSO: ≥ 40 mg/mL
Storage 3 years -20C powder
IC50 10 nM(p110δ) [1]
IUPAC Name 2-[[4-amino-3-(3-hydroxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one
InChI InChI=1S/C28H23N7O2/c1-16-7-3-4-12-21(16)35-22(32-20-11-5-8-17(2)23(20)28(35)37)14-34-27-24(26(29)30-15-31-27)25(33-34)18-9-6-10-19(36)13-18/h3-13,15,36H,14H2,1-2H3,(H2,29,30,31)
InChIKey WFSLJOPRIJSOJR-UHFFFAOYSA-N
SMILES O=C1N(C2=CC=CC=C2C)C(CN3N=C(C4=CC=CC(O)=C4)C5=C(N)N=CN=C53)=NC6=C1C(C)=CC=C6
Reference

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<br>[1]. Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.
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