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PIK-108

PIK-108

  • CAT Number: I008759
  • CAS Number: 901398-68-3
  • Molecular Formula: C22H24N2O3
  • Molecular Weight: 364.45
  • Purity: ≥95%
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PIK-108 is an allosteric inhibitor of the lipid modifying kinases, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).

Catalog Number I008759
CAS Number 901398-68-3
Synonyms

PIK-108; PIK 108; PIK108.;(S)-6-methyl-2-morpholino-8-(1-(phenylamino)ethyl)-4H-chromen-4-one

Molecular Formula

C22H24N2O3

Purity 95%
Target Allosteric Inhibitor
Solubility Soluble in DMSO
Storage 0 - 4 °C for short term, or -20 °C for long term
InChI InChI=1S/C22H24N2O3/c1-15-12-18(16(2)23-17-6-4-3-5-7-17)22-19(13-15)20(25)14-21(27-22)24-8-10-26-11-9-24/h3-7,12-14,16,23H,8-11H2,1-2H3/t16-/m0/s1
InChIKey VRCXIJAYLCUSHC-INIZCTEOSA-N
SMILES O=C1C=C(N2CCOCC2)OC3=C1C=C(C)C=C3[C@@H](NC4=CC=CC=C4)C
Reference

<br />
1.Certal V, Halley F, Virone-Oddos A, Delorme C, Karlsson A, Rak A, Thompson F, Filoche-Romm&eacute; B, El-Ahmad Y, Carry JC et al.. (2012) Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3K&beta; inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers. J. Med. Chem., 55 (10): 4788-805. [PMID:22524426]

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