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PI4KIIIbeta-IN-10

PI4KIIIbeta-IN-10

  • CAT Number: I002427
  • CAS Number: 1881233-39-1
  • Molecular Formula: C22H25N3O5S2
  • Molecular Weight: 475.58
  • Purity: ≥95%
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<p style=/line-height:25px/>PI4KIIIbeta-IN-10 is the most potent PI4KIIIβ inhibitor currently reported, with very minor off-target inhibition of PI4KIIIβ related lipid kinases (IC50 = 3.6 nM).<br>IC50 value: 3.6 nM<br>Target: PI4KIIIβ<br>in vitro: PI4KIIIbeta-IN-10 is the most potent PI4KIIIβ inhibitor currently reported, with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 1 μM), PI3Kα (10 μM), and PI4KIIIα (3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-10 is also the most effective antiviral compound in a cellular model of hepatitis C virus replication, with the best balance of antiviral potency and low cellular toxicity[1].</p>

Catalog Number I002427
CAS Number 1881233-39-1
Molecular Formula

C22H25N3O5S2

Purity 95%
Target PI4KIIIβ
Solubility DMSO: ＞ 30 mg/mL
Storage Store at -20C
IC50 3.6 nM
Reference

<p style=/line-height:25px/>
<br>[1]. Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9.
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