PI3-Kɣ Inhibitor, AS-605240

• CAT Number: I004441
• CAS Number: 648450-29-7
• Molecular Formula: C₁₂H₇N₃O₂S
• Molecular Weight: 257.27
• Purity: ≥95%
• Target: PI3K
• Solubility: DMSO: ≤ 5.8 mg/mL (Need warming)
• Storage: 2-8°C
• IC50: 8 nM
• IUPAC Name: (5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
• InChI: InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-
• InChIKey: SQWZFLMPDUSYGV-POHAHGRESA-N
• SMILES: C1=CC2=NC=CN=C2C=C1C=C3C(=O)NC(=O)S3

AS-605240 (Cat No.:I004441) is the most potent novel PI3Kγ selective inhibitor. With an IC50 of 8 nM, the selectivity for PI3Kγ is 30 and 7.5 times higher than that for PI3Kδ/β and PI3Kα, respectively. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

1:Circ Res. 2010 Jul 23;107(2):e5; author reply e6-7. doi: 10.1161/CIRCRESAHA.110.224568. Effects of PI3Kgamma inhibition using AS-605240 in acute myocardial infarction.Seropian IM,Toldo S,Abbate A,Mezzaroma E,Van Tassell BW, PMID: 20651289 DOI: 10.1161/CIRCRESAHA.110.224568