PHPS1

• CAT Number: R065983
• CAS Number: 314291-83-3
• Molecular Formula: C21H15N5O6S
• Molecular Weight: 465.44
• Purity: ≥95%
• Synonyms: 4-[[5-(4-nitrophenyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]diazenyl]benzenesulfonic acid
• InChI: InChI=1S/C21H15N5O6S/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16/h1-13,24H,(H,30,31,32)
• InChIKey: IYPHPQODKSHEHV-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)N2C(=O)C(=C(N2)C3=CC=C(C=C3)[N+](=O)[O-])N=NC4=CC=C(C=C4)S(=O)(=O)O

PHPS1 (Cat No.: R065983) is a selective small-molecule inhibitor of Src homology region 2 domain-containing phosphatase-2 (SHP2), a protein tyrosine phosphatase that regulates multiple signaling pathways downstream of growth factor receptors. By blocking SHP2 activity, PHPS1 suppresses RAS/MAPK and PI3K/AKT signaling, leading to reduced cell proliferation and survival. It is widely used as a research tool to study SHP2’s role in oncogenic signaling, immune regulation, and developmental biology. PHPS1 provides a valuable probe for validating SHP2 as a therapeutic target in cancer and immune-related diseases.

Reference

[1]. Klaus Hellmuth, et al. Specific Inhibitors of the Protein Tyrosine Phosphatase Shp2 Identified by High-Throughput Docking. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7275-80.
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[2]. Jia Chen, et al. SHP2 Inhibitor PHPS1 Protects Against Atherosclerosis by Inhibiting Smooth Muscle Cell Proliferation. BMC Cardiovasc Disord. 2018 Apr 27;18(1):72.
[Content Brief]