Phosphoramide mustard cyclohexanamine

• CAT Number: R020072
• CAS Number: 1566-15-0
• Molecular Formula: C10H24Cl2N3O2P
• Molecular Weight: 320.20
• Purity: ≥95%
• Synonyms: amino-[bis(2-chloroethyl)amino]phosphinic acid;cyclohexanamine
• InChI: InChI=1S/C6H13N.C4H11Cl2N2O2P/c7-6-4-2-1-3-5-6;5-1-3-8(4-2-6)11(7,9)10/h6H,1-5,7H2;1-4H2,(H3,7,9,10)
• InChIKey: BGTIPRUDEMNRIP-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)N.C(CCl)N(CCCl)P(=O)(N)O

Phosphoramide mustard cyclohexanamine（Cat No.:R020072）is a derivative of phosphoramide mustard, the active cytotoxic metabolite of alkylating agents like cyclophosphamide. It functions by forming DNA cross-links, leading to impaired DNA replication and cell death, particularly in rapidly dividing cancer cells. The inclusion of a cyclohexanamine moiety may modify its pharmacokinetic or lipophilic properties, potentially enhancing tissue penetration or altering toxicity. As an alkylating agent, it holds relevance in cancer chemotherapy research, especially in designing analogs with improved selectivity or reduced side effects for treating hematologic malignancies and solid tumors.