Phosphinic Acid

• CAT Number: M009451
• CAS Number: 6303-21-5
• Molecular Formula: HO2P
• Molecular Weight: 63.98
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: phosphenous acid
• InChI: InChI=1S/HO2P/c1-3-2/h(H,1,2)
• InChIKey: GQZXNSPRSGFJLY-UHFFFAOYSA-N
• SMILES: OP=O

Hypophosphorous acid is a phosphorus oxoacid and a powerful reducing agent with molecular formula H3PO2. Inorganic chemists refer to the free acid by this name (also as /HPA/), or the acceptable name of phosphinic acid. It is a colorless low-melting compound, which is soluble in water, dioxane, and alcohols. The formula for hypophosphorous acid is generally written H3PO2, but a more descriptive presentation is HOP(O)H2 which highlights its monoprotic character. Salts derived from this acid are called phosphinates (hypophosphites).

Reference

1: Liu Y, Garnham CP, Roll-Mecak A, Tanner ME. Phosphinic acid-based inhibitors
of tubulin polyglutamylases. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4408-12.
doi: 10.1016/j.bmcl.2013.05.069. Epub 2013 May 30. PubMed PMID: 23777780; PubMed
Central PMCID: PMC3725182.

2: Notni J, Šimeček J, Wester HJ. Phosphinic acid functionalized
polyazacycloalkane chelators for radiodiagnostics and radiotherapeutics: unique
characteristics and applications. ChemMedChem. 2014 Jun;9(6):1107-15. doi:
10.1002/cmdc.201400055. Epub 2014 Apr 3. Review. Erratum in: ChemMedChem. 2014
Dec;9(12):2614. PubMed PMID: 24700633.

3: Burrow RA, Siqueira da Silva RM. (9H-Fluoren-9-yl)(phen-yl)phosphinic acid.
Acta Crystallogr Sect E Struct Rep Online. 2013 Jan 1;69(Pt 1):o1. doi:
10.1107/S160053681204891X. Epub 2012 Dec 5. PubMed PMID: 23476362; PubMed Central
PMCID: PMC3588309.

4: Deep A, Sharma AL, Tuteja SK, Paul AK. Phosphinic acid functionalized carbon
nanotubes for sensitive and selective sensing of chromium(VI). J Hazard Mater.
2014 Aug 15;278:559-65. doi: 10.1016/j.jhazmat.2014.06.043. Epub 2014 Jun 28.
PubMed PMID: 25016454.

5: Burrow RA, da Silva RM. rac-Eth-yl(phen-yl)phosphinic acid. Acta Crystallogr
Sect E Struct Rep Online. 2012 Dec 1;68(Pt 12):o3488. doi:
10.1107/S160053681204812X. Epub 2012 Nov 30. PubMed PMID: 23476296; PubMed
Central PMCID: PMC3589060.