Phloretin

• CAT Number: I004296
• CAS Number: 60-82-2
• Molecular Formula: C₁₅H₁₄O₅
• Molecular Weight: 274.27
• Purity: ≥95%
• Target: GLUT1
• Solubility: DMSO 55 mg/mL; Water <1 mg/mL; Ethanol 55 mg/mL
• Storage: 2-8°C
• IC50: 49 +/- 12 microM
• IUPAC Name: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
• InChI: InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
• InChIKey: VGEREEWJJVICBM-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O

Phloretin (Cat No.:I004296) is a natural phenolic compound found in fruits like apples and strawberries. Known for its antioxidant and anti-inflammatory properties, it has garnered attention for potential health benefits. Phloretin can inhibit glucose uptake and transport, making it relevant in diabetes management. It also exhibits anticancer effects by inducing apoptosis and inhibiting tumor cell growth. Additionally, phloretin’s antioxidant properties have led to its exploration in skincare products.

Reference

1:Quercetin, Luteolin, Phloretin and Morin are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Jones RS, Parker M, Morris ME.Mol Pharm. 2017 May 17. doi: 10.1021/acs.molpharmaceut.7b00264. [Epub ahead of print] PMID: 28513167 2:Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake. Liu S, Yuan Y, Zhou Y, Zhao M, Chen Y, Cheng J, Lu Y, Liu J.J Cell Mol Med. 2017 Apr 12. doi: 10.1111/jcmm.13176. [Epub ahead of print] PMID: 28402018 Free Article3:Neuroprotective effects of phloretin and its glycosylated derivative on rotenone-induced toxicity in human SH-SY5Y neuronal-like cells. Barreca D, Currò M, Bellocco E, Ficarra S, Laganà G, Tellone E, Laura Giunta M, Visalli G, Caccamo D, Galtieri A, Ientile R.Biofactors. 2017 Apr 12. doi: 10.1002/biof.1358. [Epub ahead of print] PMID: 28401997 4:Silencing a phloretin-specific glycosyltransferase perturbs both general phenylpropanoid biosynthesis and plant development. Dare AP, Yauk YK, Tomes S, McGhie TK, Rebstock RS, Cooney JM, Atkinson RG.Plant J. 2017 Apr 2. doi: 10.1111/tpj.13559. [Epub ahead of print] PMID: 28370633 5:Phloretin Attenuates Allergic Airway Inflammation and Oxidative Stress in Asthmatic Mice. Huang WC, Fang LW, Liou CJ.Front Immunol. 2017 Feb 13;8:134. doi: 10.3389/fimmu.2017.00134. eCollection 2017. PMID: 28243240 Free PMC Article6:Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro. Shen X, Zhou N, Mi L, Hu Z, Wang L, Liu X, Zhang S.Drug Des Devel Ther. 2017 Feb 7;11:313-324. doi: 10.2147/DDDT.S127010. eCollection 2017. PMID: 28223777 Free PMC Article7:Phloretin Prevents High-Fat Diet-Induced Obesity and Improves Metabolic Homeostasis. Alsanea S, Gao M, Liu D.AAPS J. 2017 May;19(3):797-805. doi: 10.1208/s12248-017-0053-0. Epub 2017 Feb 14. PMID: 28197827 8:Phloretin Attenuates Listeria monocytogenes Virulence Both In vitro and In vivo by Simultaneously Targeting Listeriolysin O and Sortase A. Wang J, Liu B, Teng Z, Zhou X, Wang X, Zhang B, Lu G, Niu X, Yang Y, Deng X.Front Cell Infect Microbiol. 2017 Jan 19;7:9. doi: 10.3389/fcimb.2017.00009. eCollection 2017. PMID: 28154809 Free PMC Article9:Phloretin Exerts Anti-Tuberculosis Activity and Suppresses Lung Inflammation. Jeon D, Jeong MC, Jnawali HN, Kwak C, Ryoo S, Jung ID, Kim Y.Molecules. 2017 Jan 22;22(1). pii: E183. doi: 10.3390/molecules22010183. PMID: 28117761 Free Article10:Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis. Wang SP, Lin SC, Li S, Chao YH, Hwang GY, Lin CC.Evid Based Complement Alternat Med. 2016;2016:9831263. doi: 10.1155/2016/9831263. Epub 2016 Dec 4. PMID: 28044086 Free PMC Article