Phenylephrine Hydrochloride

  • CAT Number: A001003
  • CAS Number: 61-76-7
  • Molecular Formula: C9H14ClNO2
  • Molecular Weight: 203.7
  • Purity: ≥95%
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Phenylephrine HCl (CAT: A001003) is an adrenergic drug that selectively activates α1-adrenergic receptors and has a contraction effect on local body blood vessels. It is mainly used for surgical operations to prolong local anesthesia time, swelling, and anti-inflammation of nasal mucosa congestion.

Catalog Number A001003
CAS Number 61-76-7
Molecular Formula

C9H14ClNO2

Purity 95%
Target Adrenergic Receptor
Solubility Soluble in DMSO > 10 mM
Storage -20°C
InChI 1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
InChIKey OCYSGIYOVXAGKQ-FVGYRXGTSA-N
SMILES CNCC(C1=CC(=CC=C1)O)O.Cl
Reference

1: Kato M, Nitta K, Kano Y, Yamada M, Ishii N, Hashimoto T, Ohyama M. Case of
phenylephrine hydrochloride-induced periorbital contact dermatitis with fulminant
keratoconjunctivitis causing pseudomembrane formation. J Dermatol. 2017 Oct 6.
doi: 10.1111/1346-8138.14077. [Epub ahead of print] PubMed PMID: 28983944.
<br>

2: Mostafa NM, Elsayed GM, Hassan NY, El Mously DA. Development and Validation of
Eco-Friendly Liquid Chromatographic and Spectrophotometric Methods for
Simultaneous Determination of Coformulated Drugs: Phenylephrine Hydrochloride and
Prednisolone Acetate. J AOAC Int. 2017 Nov 1;100(6):1761-1770. doi:
10.5740/jaoacint.17-0001. Epub 2017 Jul 24. PubMed PMID: 28737123.
<br>

3: de Oliveira GG, Feitosa A, Loureiro K, Fernandes AR, Souto EB, Severino P.
Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine
hydrochloride in physical mixtures. Saudi Pharm J. 2017 Jan;25(1):99-103. doi:
10.1016/j.jsps.2016.05.001. Epub 2016 May 7. PubMed PMID: 28223869; PubMed
Central PMCID: PMC5310159.
<br>

4: Rezk MR, Fayed AS, Marzouk HM, Abbas SS. Chromatographic Determination of
Cyclopentolate Hydrochloride and Phenylephrine Hydrochloride in the Presence of
Their Potential Degradation Products. J AOAC Int. 2017 Mar 1;100(2):434-444. doi:
10.5740/jaoacint.16-0215. Epub 2016 Nov 30. PubMed PMID: 28118561.
<br>

5: Elfatatry HM, Mabrouk MM, Hammad SF, Mansour FR, Kamal AH, Alahmad S.
Development and Validation of Chemometric-Assisted Spectrophotometric Methods for
Simultaneous Determination of Phenylephrine Hydrochloride and Ketorolac
Tromethamine in Binary Combinations. J AOAC Int. 2016 Sep;99(5):1247-51. doi:
10.5740/jaoacint.16-0106. Epub 2016 Aug 13. PubMed PMID: 27522949.
<br>

6: Belal TS, El-Kafrawy DS, Mahrous MS, Abdel-Khalek MM, Abo-Gharam AH. Validated
spectrophotometric and chromatographic methods for simultaneous determination of
ketorolac tromethamine and phenylephrine hydrochloride. Ann Pharm Fr. 2016
Jul;74(4):267-82. doi: 10.1016/j.pharma.2015.12.006. Epub 2016 Feb 16. PubMed
PMID: 26895689.
<br>

7: El Yazbi FA, Hassan EM, Khamis EF, Ragab MA, Hamdy MM. Development and
Validation of a High-Performance Thin-Layer Chromatographic Method for the
Simultaneous Determination of Two Binary Mixtures Containing Ketorolac
Tromethamine with Phenylephrine Hydrochloride and with Febuxostat. J Chromatogr
Sci. 2016 May-Jun;54(5):819-28. doi: 10.1093/chromsci/bmv250. Epub 2016 Feb 3.
PubMed PMID: 26847918; PubMed Central PMCID: PMC4890447.

<br>
8: Meltzer EO, Ratner PH, McGraw T. Phenylephrine hydrochloride modified-release
tablets for nasal congestion: a randomized, placebo-controlled trial in allergic
rhinitis patients. Ann Allergy Asthma Immunol. 2016 Jan;116(1):66-71. doi:
10.1016/j.anai.2015.10.022. Epub 2015 Nov 7. PubMed PMID: 26560899.
<br>

9: Kryvanych O, Bevz N, Harna N, Bevz O. The use of
2,6-dichloroquinone-4chlorimide for quantitative determination of phenylephrine
hydrochloride in combined tablets with paracetamol and chlorpheniramine maleate.
Ceska Slov Farm. 2015 Nov;64(5):216-9. PubMed PMID: 28649822.
<br>

10: Gosliga JM, Barter LS. Cardiovascular effects of dopamine hydrochloride and
phenylephrine hydrochloride in healthy isoflurane-anesthetized New Zealand White
rabbits (Oryctolagus cuniculus). Am J Vet Res. 2015 Feb;76(2):116-21. doi:
10.2460/ajvr.76.2.116. PubMed PMID: 25629908.

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