Phenazepam-d4

• CAT Number: R067526
• CAS Number: 1184980-42-4
• Molecular Formula: C15H6BrClD4N2O
• Molecular Weight: 353.6
• Purity: ≥95%
• Synonyms: BD 98-d4;Fenazepam-d4
• Storage: -20°C
• InChI: InChI=1S/C15H10BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)/i1D,2D,3D,4D
• InChIKey: CGMJQQJSWIRRRL-RHQRLBAQSA-N
• SMILES: BrC1=CC2=C(N([H])C(CN=C2C3=C([2H])C([2H])=C([2H])C([2H])=C3Cl)=O)C=C1

Phenazepam-d4 contains 4 deuterium atoms. It is intended for use as an internal standard for the quantification of phenazepam by GC- or LC-mass spectrometry. Phenazepam is a benzodiazepine agonist of the GABAA-<wbr></wbr>benzodiazepine receptor chloride channel complex. It has been shown to have strong anxiolytic, sedative, anticonvulsive, and hypnotic properties in humans, as well as in animal species when administered at 1 mg/kg. At very low doses (10-<wbr></wbr>5 to 10-<wbr></wbr>10 mg/kg), phenazepam has been shown to act as an anxioselective tranquilizer.

Reference

1.Kalinina, T.S.,Garibova, T.L., and Voronina, T.A. Descriminative effects of phenazepam and gidazepam in rats: comparison with other GABA-related drugs. Pharmacology, Biochemistry, and Behavior 64(2), 397-401 (1999).