PF00835231

• CAT Number: I034464
• CAS Number: 870153-29-0
• Molecular Formula: C24H32N4O6
• Molecular Weight: 472.54
• Purity: 98%
• Synonyms: PF 00835231; PF-00835231; PF00835231; PF 835231; PF-835231; PF835231
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-[(2S)-1-[[(2S)-4-hydroxy-3-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide
• InChI: InChI=1S/C24H32N4O6/c1-13(2)9-18(23(32)27-17(20(30)12-29)10-14-7-8-25-22(14)31)28-24(33)19-11-15-16(26-19)5-4-6-21(15)34-3/h4-6,11,13-14,17-18,26,29H,7-10,12H2,1-3H3,(H,25,31)(H,27,32)(H,28,33)/t14-,17-,18-/m0/s1
• InChIKey: QDIMHKWNHMVDJB-WBAXXEDZSA-N
• SMILES: CC(C)CC(C(=O)NC(CC1CCNC1=O)C(=O)CO)NC(=O)C2=CC3=C(N2)C=CC=C3OC

PF00835231（Cat No.:I034464） is a potent inhibitor of the SARS CoV-1 3CLpro (3C-like protease), a key viral enzyme involved in the replication of coronaviruses. It has shown potential as a treatment option for COVID-19, caused by SARS CoV-2, due to its ability to target a similar protease in the SARS CoV-1 virus. By inhibiting the activity of 3CLpro, PF00835231 may impede viral replication and reduce the severity of the infection. Further research and clinical trials are needed to evaluate its effectiveness against SARS-CoV-2 and its potential as a COVID-19 therapy.

Reference

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3: de Vries M, Mohamed AS, Prescott RA, Valero-Jimenez AM, Desvignes L, O’Connor R, Steppan C, Anderson AS, Binder J, Dittmann M. Comparative study of a 3CL pro inhibitor and remdesivir against both major SARS-CoV-2 clades in human airway models. bioRxiv [Preprint]. 2020 Aug 28:2020.08.28.272880. doi: 10.1101/2020.08.28.272880. PMID: 32869028; PMCID: PMC7457613.