PF 750

• CAT Number: R013327
• CAS Number: 959151-50-9
• Molecular Formula: C22H23N3O
• Molecular Weight: 345.446
• Purity: ≥95%
• Target: FAAH
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at RT
• IUPAC Name: N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide
• InChI: InChI=1S/C22H23N3O/c26-22(24-20-7-2-1-3-8-20)25-12-10-17(11-13-25)14-18-15-19-6-4-5-9-21(19)23-16-18/h1-9,15-17H,10-14H2,(H,24,26)
• InChIKey: BIODYGOZWZNCAG-UHFFFAOYSA-N
• SMILES: C1CN(CCC1CC2=CC3=CC=CC=C3N=C2)C(=O)NC4=CC=CC=C4

PF-750 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 16.2 nM) that displays no activity at a range of other serine hydrolases. It selectively inhibits FAAH within the central nervous system.

Reference

1: Wu H, Kelley CJ, Pino-Figueroa A, Vu HD, Maher TJ. Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition. Bioorg Med Chem. 2013 Sep 1;21(17):5188-97. doi: 10.1016/j.bmc.2013.06.034. Epub 2013 Jun 27. PubMed PMID: 23891163.2: Feledziak M, Muccioli GG, Lambert DM, Marchand-Brynaert J. SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process. J Med Chem. 2011 Oct 13;54(19):6812-23. doi: 10.1021/jm200723m. Epub 2011 Sep 20. PubMed PMID: 21899370.3: Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC. Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12820-4. doi: 10.1073/pnas.0806121105. Epub 2008 Aug 27. PubMed PMID: 18753625; PubMed Central PMCID: PMC2529035.4: Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET, Nugent RA, Nomanbhoy TK, Alexander JP, Cravatt BF. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 2007 Nov 13;46(45):13019-30. Epub 2007 Oct 19. PubMed PMID: 17949010.