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PF-543

PF-543

  • CAT Number: I001588
  • CAS Number: 1415562-82-1
  • Molecular Formula: C27H31NO4S
  • Molecular Weight: 465.6
  • Purity: ≥95%
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<p style=/line-height:25px/>PF-543 is a novel cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.<br>IC50 value: 3.6 nM (Ki)<br>Target: SphK1<br>PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling.</p>

Catalog Number I001588
CAS Number 1415562-82-1
Molecular Formula

C27H31NO4S

Purity 95%
Target S1P receptor
Solubility 10 mM in DMSO
Storage 3 years -20C powder
IC50 3.6 nM (Ki)
InChIKey NPUXORBZRBIOMQ-RUZDIDTESA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Schnute ME, McReynolds MD, Kasten T et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88.
<br>[2]. Lynch KR. Building a better sphingosine kinase-1 inhibitor. Biochem J. 2012 May 15;444(1):e1-2.
</p>

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