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PF-543 Citrate

PF-543 Citrate

  • CAT Number: I001589
  • CAS Number: 1415562-83-2
  • Molecular Formula: C33H39NO11S
  • Molecular Weight: 657.73
  • Purity: ≥95%
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PF-543 Citrate (Cat.No:I001589) is a selective inhibitor of Sphingosine Kinase 1 (SphK1), an enzyme involved in the regulation of sphingolipid metabolism. By targeting SphK1, PF-543 Citrate modulates cellular signaling pathways related to cell proliferation, apoptosis, and inflammation. It holds potential as a therapeutic agent in various diseases, including cancer and inflammatory disorders.

Catalog Number I001589
CAS Number 1415562-83-2
Molecular Formula

C33H39NO11S

Purity 95%
Target SPHK
Solubility 10 mM in DMSO
Storage Store at -20°C
IC50 3.6 nM (Ki)
Reference

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<br>[1]. Schnute ME, McReynolds MD, Kasten T et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88.
<br>[2]. Lynch KR. Building a better sphingosine kinase-1 inhibitor. Biochem J. 2012 May 15;444(1):e1-2.
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