PF-4800567

• CAT Number: I008710
• CAS Number: 1188296-52-7
• Molecular Formula: C17H18ClN5O2
• Molecular Weight: 359.814
• Purity: ≥95%
• Target: Casein Kinase Inhibitor
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine
• InChI: InChI=1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21)
• InChIKey: AUMDBEHGJRZSOO-UHFFFAOYSA-N
• SMILES: C1COCCC1N2C3=C(C(=N2)COC4=CC(=CC=C4)Cl)C(=NC=N3)N

PF-4800567 (CAT: I008710) is a selective inhibitor of casein kinase 1ε (CK1ε). It exhibits a high level of selectivity for CK1ε, with an IC50 (half maximal inhibitory concentration) value of 32 nM. It demonstrates more than 20-fold selectivity over CK1δ, another isoform of casein kinase 1. Casein kinases are involved in regulating various cellular processes, including cell division, circadian rhythm, and signal transduction pathways. By specifically inhibiting CK1ε, PF-4800567 has the potential to modulate CK1ε-mediated signaling pathways and provide insights into its functional role in cellular physiology and disease processes.

Reference

1. Walton, K.M.,Fisher, K.,Rubitski, D., et al. Selective inhibition of casein kinase 1ε minimally alters circadian clock period. Journal of Pharmacology and Experimental Therapeutics 330(2), 430-439 (2009).