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PF-3758309

PF-3758309

  • CAT Number: I005375
  • CAS Number: 898044-15-0
  • Molecular Formula: C25H30N8OS
  • Molecular Weight: 490.6
  • Purity: ≥95%
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PF-3758309 (Cat.No:I005375) is a selective and potent inhibitor of focal adhesion kinase (FAK), an enzyme involved in cell signaling and tumor progression. It has shown promising anticancer activity in preclinical studies, inhibiting cell migration and invasion. PF-3758309 is being investigated for its potential as a therapeutic agent against various types of cancer.

Catalog Number I005375
CAS Number 898044-15-0
Molecular Formula

C25H30N8OS

Purity 95%
Target PAK4
Solubility 10 mM in DMSO
Storage Store at -20°C
IC50 1.3 nM (PAK4)
InChIKey AYCPARAPKDAOEN-LJQANCHMSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Murray, Brion W.; Guo, Chuangxing; Piraino, Joseph. Small-molecule p21-activated kinase inhibitor PF3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proceedings of the National Academy of Sciences of the United States of America (2010), 107(20), 9446-9451, S9446/1-S9446/18.
<br>[2]. Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M, Kraynov E, Popoff I, Christensen JG, Martinez R, Kephart SE, Marakovits J, Karlicek S, Bergqvist S, Smeal T. Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51.
<br>[3]. Zhao ZS, Manser E. Do PAKs make good drug targets? F1000 Biol Rep. 2010 Sep 23;2:70.
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