Perlapine

• CAT Number: R032986
• CAS Number: 1977-11-3
• Molecular Formula: C19H21N3
• Molecular Weight: 291.398
• Purity: ≥95%
• Synonyms: 6-(4-Methyl-1-piperazinyl)-morphanthridine; 6-(4-Methyl-1-piperazinyl)morphanthridine; AW 142333; HF 2333; Hypnodin; MP 11;?NSC 291840?
• Target: hM3Dq DREADD agonist
• Storage: -20°C
• IUPAC Name: 6-(4-methylpiperazin-1-yl)-11H-benzo[c][1]benzazepine
• InChI: InChI=1S/C19H21N3/c1-21-10-12-22(13-11-21)19-17-8-4-2-6-15(17)14-16-7-3-5-9-18(16)20-19/h2-9H,10-14H2,1H3
• InChIKey: PWRPUAKXMQAFCJ-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=NC3=CC=CC=C3CC4=CC=CC=C42

Perlapine is a potent and selective hM3Dq DREADD agonist (EC50 = 2.8 nM). This drug exhibits >10,000-fold selectivity for hM3Dq over hM3.

Reference

1:Perlapine: relationship between stimulation of prolactin secretion and antipsychotic activity. Meltzer HY, Fessler RG, Fang VS.Psychopharmacology (Berl). 1977 Oct 20;54(2):183-6. PMID: 412213 2:Perlapine and dopamine metabolism: prediction of antipsychotic efficacy. Wilk S, Stanley M.Eur J Pharmacol. 1977 Jan 7;41(1):65-72. PMID: 12986 3:Effects of clozapine, thioridazine, perlapine and haloperidol on the metabolism of the biogenic amines in the brain of the rat. Bürki HR, Ruch W, Asper H.Psychopharmacologia. 1975;41(1):27-33. PMID: 235767 4:The effects of perlapine on sleep. Allen SR, Oswald I.Psychopharmacologia. 1973 Aug 22;32(1):1-9. No abstract available. PMID: 4359662 5:6-(4-Methyl-1-piperazinyl)morphanthridine (Perlapine), a new tricyclic compound with sedative and sleep-promoting properties. A pharmacological study. Stille G, Sayers A, Lauener H, Eichenberger E.Psychopharmacologia. 1973 Feb 20;28(4):325-37. No abstract available. PMID: 4695567