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PERK-IN-44

PERK-IN-44

  • CAT Number: I034454
  • CAS Number: 1883548-84-2
  • Molecular Formula: C34H29ClN4O2
  • Molecular Weight: 561.08
  • Purity: 98%
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AMGPERK44（Cat No.:I034454） is a potent and orally active inhibitor that selectively targets the protein kinase RNA-like endoplasmic reticulum kinase (PERK). With an IC50 value of 6nM, it displays a high affinity for PERK. AMGPERK44 exhibits remarkable selectivity for PERK, being 1000-fold more selective for PERK than GCN2 and 160-fold more selective for B-Raf. Additionally, AMGPERK44 can induce autophagy, a cellular process involved in the recycling and degradation of cellular components.

Catalog Number I034454
CAS Number 1883548-84-2
Molecular Formula

C34H29ClN4O2

Purity 98
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride
InChI InChI=1S/C34H28N4O2.ClH/c1-21-14-18-27(31(35)29(21)25-17-19-28-24(20-25)16-15-22(2)36-28)33(39)30-32(23-10-6-4-7-11-23)37(3)38(34(30)40)26-12-8-5-9-13-26;/h4-20H,35H2,1-3H3;1H
InChIKey RNAKBTDDCHJCMT-UHFFFAOYSA-N
SMILES O=C1N(C2=CC=CC=C2)N(C)C(C3=CC=CC=C3)=C1C(C4=CC=C(C)C(C5=CC=C6N=C(C)C=CC6=C5)=C4N)=O.[H]Cl

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