Peramivir

• CAT Number: I003184
• CAS Number: 330600-85-6
• Molecular Formula: C15H28N4O4
• Molecular Weight: 328.41
• Purity: ≥95%
• Synonyms: (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.09 nM
• InChI: InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12-,13+/m0/s1
• InChIKey: XRQDFNLINLXZLB-CKIKVBCHSA-N
• SMILES: CCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C

PEO-IAA (Cat.No:I003184) is a synthetic compound that acts as a potent auxin antagonist. It binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs). PEO-IAA inhibits the expression of growth-responsive genes, such as ZmSAUR2, and impedes gravitropic bending. It is a valuable tool for studying auxin signaling pathways and plant development.

Reference

[1]. Efficacy, safety, and pharmacokinetics of intravenous peramivir in children with 2009 pandemic H1N1 influenza A virus infection By Sugaya, Norio; Kohno, Shigeru; Ishibashi, Toru; Wajima, Toshihiro; Takahashi, Takao From Antimicrobial Agents and Chemotherapy.
[2]. Louie JK, Yang S, Yen C, Acosta M, Schechter R, Uyeki TM. Use of Intravenous Peramivir for Treatment of Severe Influenza A(H1N1)pdm09. PLoS One. 2012;7(6):e40261.
[3]. Sakata H. Clinical efficiency in children treated with intravenous drip infusion of peramivir.Jpn J Antibiot. 2011 Dec;64(6):383-7.
[4]. Abed Y, Pizzorno A, Boivin G. Therapeutic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H275Y Neuraminidase Mutation. Antimicrob Agents Chemother. 2012 Aug;56(8):4375-80.
[5]. Hikita T, Hikita H, Hikita F, Hikita N, Hikita S. Clinical effectiveness of peramivir in comparison with other neuraminidase inhibitors in pediatric influenza patients.Int J Pediatr. 2012;2012:834181.