Pepstatin A

• CAT Number: I002902
• CAS Number: 26305-03-3
• Molecular Formula: C₃₄H₆₃N₅O₉
• Molecular Weight: 685.89
• Purity: ≥95%
• Target: Other Proteases
• Solubility: DMSO: ≥ 25 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C35H64N4O9/c1-18(2)12-24(40)15-25(21(7)8)34(47)39-32(22(9)10)35(48)38-26(13-19(3)4)28(41)16-30(43)36-23(11)33(46)37-27(14-20(5)6)29(42)17-31(44)45/h18-23,25-29,32,41-42H,12-17H2,1-11H3,(H,36,43)(H,37,46)(H,38,48)(H,39,47)(H,44,45)/t23-,25-,26-,27
• InChIKey: FJJYRFSPJZDANJ-IJMJMNMJSA-N
• SMILES: CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(CC(=O)CC(C)C)C(C)C)O

Pepstatin A (CAT: I002902) is a potent and reversible inhibitor of acid proteases, particularly cathepsins D and E. It acts by binding to the active site of these enzymes, preventing their proteolytic activity. Pepstatin A is commonly used in biochemical and cellular research to inhibit acid proteases and investigate their functions. It has been particularly valuable in studying the role of cathepsins in various biological processes, including protein degradation, autophagy, and immune response. Additionally, pepstatin A has been explored as a potential therapeutic agent for diseases involving excessive activity of acid proteases, such as certain cancers and neurodegenerative disorders.

Reference

[1]. Umezawa H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo). 1970 May;23(5):259-62.
[2]. Deiss LP, et al. Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J. 1996 Aug 1;15(15):3861-70.
[3]. Wu GS, et al. Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene. 1998 Apr 30;16(17):2177-83.
[4]. Athanassakis I, et al. Localization of pepstatin/’s inhibitory action during Fc-mediated antibody internalization: possible implications for antibody-mediated viral transmission. Cell Immunol. 2000 Feb 1;199(2):81-8.