Pentoxifylline

• CAT Number: I000055
• CAS Number: 6493-05-6
• Molecular Formula: C13H18N4O3
• Molecular Weight: 278.3
• Purity: ≥95%
• Target: PDE
• Solubility: DMSO: ≥ 2.8 mg/mL
• Storage: -20°C
• InChI: InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3
• InChIKey: BYPFEZZEUUWMEJ-UHFFFAOYSA-N
• SMILES: CC(CCCCN1C(N(C)C(N=CN2C)=C2C1=O)=O)=O

Pentoxifylline (Cat.No:I000055) is a medication with multiple pharmacological actions. It acts as a blood flow enhancer by improving the flexibility of red blood cells and reducing blood viscosity. It is used in the treatment of peripheral vascular diseases, such as intermittent claudication, and has anti-inflammatory properties. Pentoxifylline has demonstrated benefits in various conditions, including circulatory disorders and chronic inflammatory diseases.

Reference

1:Effect of Pentoxifylline in Ameliorating Myocardial Injury in Patients With Myocardial Infarction Undergoing Thrombolytic Therapy: A Pilot Randomized Clinical Trial. Namdar H, Zohori R, Aslanabadi N, Entezari-Maleki T.J Clin Pharmacol. 2017 May 17. doi: 10.1002/jcph.926. [Epub ahead of print] PMID: 28513852 2:Oral Pentoxifylline Associated with Pentavalent Antimony: A Randomized Trial for Cutaneous Leishmaniasis. Brito G, Dourado M, Guimarães LH, Meireles E, Schriefer A, de Carvalho EM, Machado PRL.Am J Trop Med Hyg. 2017 May;96(5):1155-1159. doi: 10.4269/ajtmh.16-0435. PMID: 28500815 3:Administration of pentoxifylline to improve anemia of hemodialysis patients. Shahbazian H, Ghorbani A, Zafar-Mohtashami A, Balali A, AleAli A, Lashkarara GR.J Renal Inj Prev. 2016 Nov 26;6(1):61-64. doi: 10.15171/jrip.2017.11. eCollection 2017. PMID: 28487874 Free PMC Article4:Repurposing Pentoxifylline for the Treatment of Fibrosis: An Overview. Wen WX, Lee SY, Siang R, Koh RY.Adv Ther. 2017 May 8. doi: 10.1007/s12325-017-0547-2. [Epub ahead of print] Review. PMID: 28484954 5:Pentoxifylline and prevention of contrast-induced nephropathy: Is it efficient in patients with myocardial infarction undergoing coronary angioplasty? Eshraghi A, Naranji-Sani R, Pourzand H, Vojdanparast M, Morovatfar N, Ramezani J, Khamene-Bagheri R, Nezafati P.ARYA Atheroscler. 2016 Sep;12(5):238-242. PMID: 28458699 Free PMC Article6:Pentoxifylline increase sperm motility in devitrified spermatozoa from asthenozoospermic patient without damage chromatin and DNA integrity. Nabi A, Khalili MA, Fesahat F, Talebi A, Ghasemi-Esmailabad S.Cryobiology. 2017 Apr 25. pii: S0011-2240(16)30371-6. doi: 10.1016/j.cryobiol.2017.04.008. [Epub ahead of print] PMID: 28455156 7:Pentoxifylline plus ACEIs/ARBs for proteinuria and kidney function in chronic kidney disease: a meta-analysis. Liu D, Wang LN, Li HX, Huang P, Qu LB, Chen FY.J Int Med Res. 2017 Apr;45(2):383-398. doi: 10.1177/0300060516663094. Epub 2017 Jan 1. PMID: 28415944 8:The effects of pentoxifylline adminstration on fracture healing in a postmenopausal osteoporotic rat model. Vashghani Farahani MM, Ahadi R, Abdollahifar M, Bayat M.Lab Anim Res. 2017 Mar;33(1):15-23. doi: 10.5625/lar.2017.33.1.15. Epub 2017 Mar 27. PMID: 28400835 Free PMC Article9:Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Kang Y, Yan W, Fang H, Zhang G, Du Y, Wang L, Cui H, Shi G.Oxid Med Cell Longev. 2017;2017:7908072. doi: 10.1155/2017/7908072. Epub 2017 Mar 12. PMID: 28386312 Free PMC Article10:Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis. Lee JG, Shim S, Kim MJ, Myung JK, Jang WS, Bae CH, Lee SJ, Kim KM, Jin YW, Lee SS, Park S.Biomed Res Int. 2017;2017:1279280. doi: 10.1155/2017/1279280. Epub 2017 Feb 27. PMID: 28337441 Free PMC Article