Penfluridol

• CAT Number: A000558
• CAS Number: 26864-56-2
• Molecular Formula: C28H27ClF5NO
• Molecular Weight: 523.97
• Purity: ≥95%
• Synonyms: 26864-56-2; 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol; Semap; TLP-607; McN-JR-16,341
• Storage: 3 years -20C powder
• InChI: 1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2
• InChIKey: MDLAAYDRRZXJIF-UHFFFAOYSA-N
• SMILES: C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F

Penfluridol, also known as R-16341 and Semap, is long-acting anti-psychotic agent used for maintenance or long-term therapy of schizophrenia and other psychotic disorders. Penfluridol distributes extensively in fatty tissues following oral administration. This depot effect produces a very slow release of drug from the tissues, and results in a very long duration of activity. 3. Penfluridol is extensively metabolized by oxidative N-dealkylation to afford, as isolated metabolites, the beta-glucuronide conjugate of the diphenylbutyric acid derivative A1 and the unconjugated basic piperidine moiety B1.

Reference

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schizophrenia. Cochrane Database Syst Rev. 2017 Sep 23;9:CD011831. doi:
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2: Du J, Shang J, Chen F, Zhang Y, Yin N, Xie T, Zhang H, Yu J, Liu F. A
CRISPR/Cas9-based screening for non-homologous end joining inhibitors reveals
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8: Ranjan A, Gupta P, Srivastava SK. Penfluridol: An Antipsychotic Agent
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9: Wu L, Liu YY, Li ZX, Zhao Q, Wang X, Yu Y, Wang YY, Wang YQ, Luo F. Anti-tumor
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