Pemetrexed

• CAT Number: I001434
• CAS Number: 137281-23-3
• Molecular Formula: C₂₀H₂₁N₅O₆
• Molecular Weight: 427.41
• Purity: ≥95%
• Target: Antifolate
• Solubility: DMSO 1mg/mL Water 94 mg/mL Ethanol <1 mg/mL
• Storage: 2-8°C(protect from light)
• IC50: 1.3nM(Ki for TS); 7.2nM(DHFR); 65nM(GARFT)
• IUPAC Name: (2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
• InChI: InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
• InChIKey: WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
• SMILES: C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O

Pemetrexed (Cat No.:I001434) is an antifolate. Pemetrexed inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide nucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Shih C, Chen VJ, Gossett LS, LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23.

[2]. Müller C, Reddy JA, Leamon CP, Effects of the antifolates pemetrexed and CB3717 on the tissue distribution of (99m)Tc-EC20 in xenografted and syngeneic tumor-bearing mice. Mol Pharm. 2010 Apr 5;7(2):597-604.

[3]. Rudin CM, Brahmer JR, Juergens RA, Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer.J Thorac Oncol. 2013 May;8(5):619-23.