PEG8-Tos

• CAT Number: I016969
• CAS Number: 886469-23-4
• Molecular Formula: C₂₃H₄₀O₁₁S
• Molecular Weight: 524.62
• Purity: ≥95%

PEG8-Tos (CAT: I016969) is a polyethylene glycol (PEG)-based linker commonly utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). With its tosylate functional group, this linker is designed to facilitate the conjugation of various protein-targeting ligands. PEG8-Tos serves as a critical component in PROTAC design, enabling the specific degradation of target proteins by forming bifunctional molecules that recruit E3 ligases to the target protein.

Reference

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.