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PD318088

PD318088

  • CAT Number: I003434
  • CAS Number: 391210-00-7
  • Molecular Formula: C₁₆H₁₃BrF₃IN₂O₄
  • Molecular Weight: 561.09
  • Purity: ≥95%
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PD318088 (Cat.No:I003434) is a potent and selective inhibitor of cyclin-dependent kinase 2 (CDK2), a key enzyme involved in cell cycle regulation. It has been studied for its potential applications in cancer therapy. PD318088 exhibits anti-proliferative effects on cancer cells and shows promise as a targeted therapy against CDK2-dependent tumors.

Catalog Number I003434
CAS Number 391210-00-7
Synonyms

5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide

Molecular Formula

C₁₆H₁₃BrF₃IN₂O₄

Purity 95%
Target MEK1/2
Solubility DMSO ≥110mg/mL Water <1.2mg/mL Ethanol ≥12mg/mL
Storage 3 years -20C powder
InChI InChI=1S/C16H13BrF3IN2O4/c17-10-4-9(16(26)23-27-6-8(25)5-24)15(14(20)13(10)19)22-12-2-1-7(21)3-11(12)18/h1-4,8,22,24-25H,5-6H2,(H,23,26)
InChIKey XXSSGBYXSKOLAM-UHFFFAOYSA-N
SMILES C1=CC(=C(C=C1I)F)NC2=C(C(=C(C=C2C(=O)NOCC(CO)O)Br)F)F
Reference

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<br>[1]. Ohren JF, et al. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol, 2004, 11(12), 1192-1197.
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