For research use only. Not for therapeutic Use.
PD0325901-O-C2-dioxolane（Cat No.:I045766）is a derivative of PD0325901, a highly selective MEK1/2 inhibitor that blocks the MAPK/ERK signaling pathway, critical in cell proliferation and survival. The O-C2-dioxolane modification enhances structural versatility, making it useful for medicinal chemistry optimization and mechanistic studies. Researchers apply this compound in cancer research to probe resistance mechanisms, refine kinase selectivity, and evaluate structure–activity relationships. Its defined modification provides a scaffold for developing next-generation MEK inhibitors, supporting drug discovery efforts targeting oncogenic signaling and advancing therapeutic strategies in oncology and precision medicine.
| CAS Number | 2581116-22-3 |
| Synonyms | N-[2-(1,3-dioxolan-2-yl)ethoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide |
| Molecular Formula | C18H16F3IN2O4 |
| Purity | ≥95% |
| IUPAC Name | N-[2-(1,3-dioxolan-2-yl)ethoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide |
| InChI | InChI=1S/C18H16F3IN2O4/c19-12-3-2-11(18(25)24-28-6-5-15-26-7-8-27-15)17(16(12)21)23-14-4-1-10(22)9-13(14)20/h1-4,9,15,23H,5-8H2,(H,24,25) |
| InChIKey | OGHJINAFAYYQDK-UHFFFAOYSA-N |
| SMILES | C1COC(O1)CCONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
