Leonurine

• CAT Number: I002833
• CAS Number: 24697-74-3
• Molecular Formula: C14H21N3O5
• Molecular Weight: 311.33
• Purity: ≥95%
• Solubility: DMSO: ≤ 6 mg/mL (Need ultrasonic)
• Storage: -20°C

Leonurine, a natural alkaloid extracted from Herba leonuri, has been proved to have anti-inflammatory effect.IC50﹠Target:In Vitro: Leonurine can obviously attenuate the spontaneous excitatory postsynaptic current amplitude and frequency on pyramidal neurons[1]. Leonurine can dose-dependently suppress PI glycation. Leonurine may inhibit PI glycation through trapping MGO and keeping it from reacting with PI[2].In Vivo: Leonurine (60 mg/kg/day) + 2-VO significantly decreases levels of glutamate and hydrogen peroxide, improves both the cognitive flexibility and the spatial learning and memory abilities. Moreover, leonurine obviously enhances long-term depression, elevates the ratio of N-methyl-D-aspartate receptor 2A/2B, and decreases the expression of postsynaptic density protein-95. Interestingly, the ratio of LC3II/LC3I and beclin-1 expression were markedly down-regulated by leonurine[1]. Leonurine significantly alleviates LPS-induced histopathological changes, downregulates the levels of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), upregulates the level of anti-inflammatory cytokine interleukin-10 (IL-10), and inhibits the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in mouse mastitis model. Leonurine inhibits the expression of Toll-like receptor 4 (TLR4) and the activation of nuclear factor-kappaB (NF-κB) and the phosphorylation of p38, extracellular signal-regulated kinase (ERK), and Jun N-terminal kinase (JNK)[4].

Reference

[1]. Liu C, et al. Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy. Phytomedicine. 2016 Dec 1;23(13):1638-1646.
[2]. Gao H, et al. Synthesis and biological evaluation of the codrug of Leonurine and Aspirin as cardioprotective agents. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4650-4.
[3]. Huang L, et al. Inhibitory effect of leonurine on the formation of advanced glycation end products. Food Funct. 2015 Feb;6(2):584-9.
[4]. Song X, et al. Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in LPS-induced mouse mastitis. Inflammation. 2015 Feb;38(1):79-88.
[5]. Xu D, et al. Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-κB signaling pathway. Fitoterapia. 2014 Sep;97:148-55.