PD0166285

• CAT Number: I008570
• CAS Number: 185039-89-8
• Molecular Formula: C26H27Cl2N5O2
• Molecular Weight: 512.435
• Purity: ≥95%
• Target: Chk1 inhibitor
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one
• InChI: InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)
• InChIKey: IFPPYSWJNWHOLQ-UHFFFAOYSA-N
• SMILES: CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl

PD0166285(CAT: I008570) is a potent inhibitor of Wee1 kinase and Chk1 kinase. It acts at nanomolar concentrations to inhibit the activity of these kinases, which are involved in cell cycle regulation and DNA damage response. By inhibiting Wee1 and Chk1, PD0166285 can disrupt the cell cycle progression, induce DNA damage, and potentially enhance the efficacy of DNA-damaging agents in cancer therapy. It has been studied as a potential anticancer agent, particularly in combination with chemotherapy or radiation therapy. However, further research and clinical studies are necessary to fully understand its therapeutic applications and determine its safety and efficacy in treating cancer.

Reference

1:Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. Hashimoto O, Shinkawa M, Torimura T, Nakamura T, Selvendiran K, Sakamoto M, Koga H, Ueno T, Sata M.BMC Cancer. 2006 Dec 19;6:292. PMID: 17177986 Free PMC Article
2:Wild-type TP53 inhibits G(2)-phase checkpoint abrogation and radiosensitization induced by PD0166285, a WEE1 kinase inhibitor. Li J, Wang Y, Sun Y, Lawrence TS.Radiat Res. 2002 Mar;157(3):322-30. PMID: 11839095
3:Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Wang Y, Li J, Booher RN, Kraker A, Lawrence T, Leopold WR, Sun Y.Cancer Res. 2001 Nov 15;61(22):8211-7. PMID: 11719452 Free Article