PD 146176

• CAT Number: I008607
• CAS Number: 4079-26-9
• Molecular Formula: C15H11NS
• Molecular Weight: 237.32
• Purity: ≥95%
• Synonyms: PD 146176; PD-146176; PD146176; NSC 168807; NSC-168807; NSC168807.;6,11-dihydro-[1]benzothiopyrano[4,3-b]indole
• Target: 5-Lipoxygenase
• Solubility: Soluble in DMSO
• Storage: Store at 4 °C
• IUPAC Name: 6,11-dihydrothiochromeno[4,3-b]indole
• InChI: InChI=1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
• InChIKey: ZGOOPZVQMLHPFM-UHFFFAOYSA-N
• SMILES: C1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24

PD146176 (Cat No.:I008607), also known as NSC168807, is a highly potent inhibitor of 15-lipoxygenase (15-LO), an enzyme involved in the biosynthesis of various lipid mediators. It exhibits a Ki value of 197 nM for rabbit reticulocyte 15-LO, indicating strong binding affinity. By inhibiting 15-LO, PD146176 can modulate the production of inflammatory lipid metabolites, offering potential therapeutic applications in diseases associated with excessive 15-LO activity, such as inflammation, asthma, and cardiovascular disorders.

Reference

1:Baragatti B, Coceani F. Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen. Can J Physiol Pharmacol. 2011 May;89(5):329-34. doi: 10.1139/y11-025. PubMed PMID: 21619415.2:Mangino MJ, Brounts L, Harms B, Heise C. Lipoxin biosynthesis in inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 2006 Mar;79(1-2):84-92. PubMed PMID: 16516812.