PC945

• CAT Number: I016665
• CAS Number: 1931946-73-4
• Molecular Formula: C₃₈H₃₇F₃N₆O₃
• Molecular Weight: 682.73
• Purity: ≥95%

PC945 (Cat No.: I016665) is a powerful and durable antifungal drug that effectively targets a wide range of Aspergillus fumigatus strains, including those that have developed resistance to other azole-based antifungal drugs. It acts by inhibiting the activity of two critical enzymes, CYP51A and CYP51B, which are responsible for the production of ergosterol, a vital component of fungal cell membranes. PC945 exhibits high potency with IC50s of 0.23 μM and 0.22 μM against CYP51A and CYP51B, respectively.

Reference

[1]. Colley T, et al. In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16.[2]. Colley T, et al. Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection. Sci Rep. 2019 Jul 1;9(1):9482.