PC786

• CAT Number: I034283
• CAS Number: 1902114-15-1
• Molecular Formula: C41H38FN5O4S
• Molecular Weight: 715.84
• Purity: 98%
• Synonyms: PC-786; PC 786; PC786
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-(2-Fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide
• InChI: InChI=1S/C41H38FN5O4S/c1-25-20-31(37(43-22-25)46-23-41(24-46)15-18-51-19-16-41)38(48)44-29-12-10-27(11-13-29)40(50)47-17-14-28-21-34(52-36(28)30-7-3-4-9-33(30)47)39(49)45-35-26(2)6-5-8-32(35)42/h3-13,20-22H,14-19,23-24H2,1-2H3,(H,44,48)(H,45,49)
• InChIKey: VTCJNYICQADBJD-UHFFFAOYSA-N
• SMILES: O=C(C(S1)=CC2=C1C3=CC=CC=C3N(C(C4=CC=C(NC(C5=C(N6CC7(CCOCC7)C6)N=CC(C)=C5)=O)C=C4)=O)CC2)NC8=C(C)C=CC=C8F

PC786（Cat No.:I034283） is a potent inhibitor of respiratory syncytial virus (RSV) L-protein polymerase that does not act as a nucleoside. This small molecule has demonstrated strong antiviral activity against RSV in vitro and in vivo and is thought to interfere with the viral replication process by inhibiting the activity of the L-protein polymerase. PC786 has potential as a treatment for RSV infections and is currently being evaluated in clinical trials.

Reference

1: Mirabelli C, Jaspers M, Boon M, Jorissen M, Koukni M, Bardiot D, Chaltin P, Marchand A, Neyts J, Jochmans D. Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium. J Antimicrob Chemother. 2018 Mar 27. doi: 10.1093/jac/dky089. [Epub ahead of print] PubMed PMID: 29596680; PubMed Central PMCID: PMC6005027.
2: Brookes DW, Coates M, Allen H, Daly L, Constant S, Huang S, Hows M, Davis A, Cass L, Ayrton J, Knowles I, Strong P, Rapeport G, Ito K. Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium. Br J Pharmacol. 2018 Jun;175(12):2520-2534. doi: 10.1111/bph.14221. Epub 2018 May 2. PubMed PMID: 29579332; PubMed Central PMCID: PMC5980447.
3: Coates M, Brookes D, Kim YI, Allen H, Fordyce EAF, Meals EA, Colley T, Ciana CL, Parra GF, Sherbukhin V, Stockwell JA, Thomas JC, Hunt SF, Anderson-Dring L, Onions ST, Cass L, Murray PJ, Ito K, Strong P, DeVincenzo JP, Rapeport G. Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00737-17. doi: 10.1128/AAC.00737-17. Print 2017 Sep. PubMed PMID: 28652242; PubMed Central PMCID: PMC5571287.