Pazopanib HCl (GW786034 HCl)

• CAT Number: A000401
• CAS Number: 635702-64-6
• Molecular Formula: C21H24ClN7O2S
• Molecular Weight: 473.98
• Purity: ≥95%
• Target: VEGFR
• Solubility: >11.9mg/mL in DMSO
• Storage: 3 years -20C powder

Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively.Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM.The mice treated with 30 mg/kg or 100 mg/kg Pazopanib reveals a significant decrease in tumor burden compared with the mice treated with vehicle or 10 mg/kg Pazopanib. Treatment with Pazopanib is well-tolerated and there is no significant difference in the body weight among the mice in each group.