Pargyline hydrochloride

• CAT Number: I003079
• CAS Number: 306-07-0
• Molecular Formula: C₁₁H₁₃N.HCl
• Molecular Weight: 195.69
• Purity: ≥95%
• Target: MAO
• Solubility: DMSO：≥ 32 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H
• InChIKey: BCXCABRDBBWWGY-UHFFFAOYSA-N
• SMILES: CN(CC#C)CC1=CC=CC=C1.Cl

Pargyline hydrochloride is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension.

Reference

1:Hepatotoxicity of pargyline hydrochloride. Lowe MC.Proc West Pharmacol Soc. 1978;21:215. No abstract available. PMID: 693498 2:[Effect of iproniazid phosphate and pargyline hydrochloride on oxygen consumption, glucose and mitochondrial oxidative phosphorylation of the rat brain in vitro]. González Martínez JL, Saiz I, Velasco A, García de Jalón PD.Arch Farmacol Toxicol. 1977 Dec;3(3):259-66. Spanish. No abstract available. PMID: 613983 3:On the mechanism of reversal of reserpine action by pargyline hydrochloride. Chopra YM, Dandiya PC.Arch Int Pharmacodyn Ther. 1969 Sep;181(1):47-56. No abstract available. PMID: 5350784 4:[Effects of pargyline hydrochloride on the arterial pressure. I]. Carvalhal S, Ferracci A, Sustowich D, Mantovani M.Hospital (Rio J). 1968 Nov;74(5):1441-52. Portuguese. No abstract available. PMID: 5305322 5:A unique antihypertensive combination–pargyline hydrochloride and methyclothiazide: a controlled study of twenty-five patients over a nine-month period. Fletcher FW.Curr Ther Res Clin Exp. 1968 Aug;10(8):394-8. No abstract available. PMID: 4970052 6:[Clinical experience using pargyline hydrochloride in the treatment of arterial hypertension]. Cantalapiedra Alsedo JL, Del Pozo P.Rev Clin Esp. 1968 Apr 15;109(1):57-62. Spanish. No abstract available. PMID: 5738826 7:Pargyline hydrochloride, methyclothiazide, and deserpidine in therapy of hypertension and prevention of /cheese reaction/. Hutchison JC.Curr Ther Res Clin Exp. 1968 Mar;10(3):128-35. No abstract available. PMID: 4967000 8:The effect of prolonged administration of pargyline hydrochloride (a non-hydrazine monoamine oxidase inhibitor) on glucose utilization in dogs. Goodsell EB, Krause RA.Arch Int Pharmacodyn Ther. 1968 Feb;171(2):475-90. No abstract available. PMID: 5685843 9:Pargyline hydrochloride poisoning in a child. Lipkin D, Kushnick T.JAMA. 1967 Jul 3;201(1):135-6. No abstract available. PMID: 6071697 10:[Clinical evaluation of pargyline hydrochloride in the therapy of arterial hypertension]. Hergueta G, García de Guadiana.Rev Esp Cardiol. 1967 Jul;20(3):387-95. Spanish. No abstract available. PMID: 5613891