Palmitic Acid

• CAT Number: R056889
• CAS Number: 57-10-3
• Molecular Formula: C16H32O2
• Molecular Weight: 256.43
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: hexadecanoic acid
• InChI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
• InChIKey: IPCSVZSSVZVIGE-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)O

Saturated fatty acids are synthesized by both plants and animals from acetyl coenzyme A as a form of long-<wbr></wbr>term energy storage. Palmitic acid is a common 16-<wbr></wbr>carbon saturated fat that represents 10-<wbr></wbr>20% of the normal human dietary fat intake. Palmitic acid also makes up approximately 25% of the total plasma fatty acids in plasma lipoproteins. Saturated free fatty acids induce the expression of cyclooxygenase-<wbr></wbr>2, and after protein acylation, are used to confer lipid anchoring to a variety of signaling molecules.

Reference

1. S. Benoit et al. “Palmitic acid mediates hypothalamic insulin resistance by altering PKC-? subcellular localization in rodents” Journal of ClinicalInvestigation, vol. 119 pp. 2577-2589, 20092. H. Iijima et al. “The Inhibitory Action of Long-Chain Fatty Acids on the DNA Binding Activity of p53” Lipids, vol. 41 pp. 521-527, 20063. H. Liang et al. “Palmitic acid-induced apoptosis in pancreatic ?-cells is increased by liver X receptor agonist and attenuated by eicosapentaenoate” InVivo, vol. 25 pp. 711-718, 20114. R. Micha and D. Mozaffarian “Saturated Fat and Cardiometabolic Risk Factors, Coronary Heart Disease, Stroke, and Diabetes: a Fresh Look at theEvidence” Lipids, vol. 45 pp. 893-905, 2010