For research use only. Not for therapeutic Use.
PA-9 (Cat No.: I034143) is a small-molecule inhibitor targeting platelet-activating factor (PAF) receptor–mediated signaling, which plays a key role in inflammation, thrombosis, and allergic responses. By blocking PAF receptor activation, PA-9 reduces downstream inflammatory mediator release, platelet aggregation, and vascular permeability. It is studied for potential therapeutic applications in inflammatory diseases, cardiovascular disorders, and immune-mediated conditions. PA-9 is also used as a research tool to investigate PAF’s role in pathophysiology, offering insights into drug development strategies aimed at modulating PAF-driven pathological processes.
| CAS Number | 1436004-46-4 |
| Synonyms | N-[2-(1H-imidazol-5-yl)ethyl]-1-(1H-indazol-3-yl)-5-oxopyrrolidine-3-carboxamide |
| Molecular Formula | C17H18N6O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H18N6O2/c24-15-7-11(17(25)19-6-5-12-8-18-10-20-12)9-23(15)16-13-3-1-2-4-14(13)21-22-16/h1-4,8,10-11H,5-7,9H2,(H,18,20)(H,19,25)(H,21,22) |
| InChIKey | WWPHFXOMYQJGGF-UHFFFAOYSA-N |
| SMILES | C1C(CN(C1=O)C2=NNC3=CC=CC=C32)C(=O)NCCC4=CN=CN4 |
| Reference | [1]. Takasaki I, et al. In Silico Screening Identified Novel Small-molecule Antagonists of PAC1 Receptor. J Pharmacol Exp Ther. 2018 Apr;365(1):1-8. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
